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Colin Farrell’s son has a rare disorder called Angelman syndrome—what is it?

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Colin Farrell’s son, James, has inspired the actor to embark on a mission to raise awareness and support for those with intellectual disabilities. James, who has Angelman syndrome, a rare neurogenetic disorder, has been at the center of Farrell’s world for the past 20 years. This condition, which affects the nervous system, can lead to developmental delays, lack of speech, seizures, and issues with movement and balance. Despite these challenges, James has been a source of immense joy and strength for his father.

At 48 years old, Farrell is now using his platform to make a difference for others who face similar challenges. In a deeply emotional interview with People magazine, Farrell expressed his profound wish for the world to treat his son with kindness and respect. “I want the world to be kind to James,” he said, highlighting the struggles that come with navigating life with an intellectual disability.

One of Farrell’s biggest concerns is the lack of social support for individuals with intellectual disabilities as they transition into adulthood. Many of the resources available to children disappear once they reach the age of 21, leaving families struggling to find adequate support. This concern has become increasingly personal for Farrell as James approaches his 21st birthday.

Recognizing the need for change, Farrell has decided to take action by launching the Colin Farrell Foundation. The foundation will focus on advocating for increased Medicaid funding, expanded housing access for people with intellectual disabilities, and higher wages for professional caretakers who play a crucial role in the lives of these individuals.

Farrell’s hope is that by raising awareness and pushing for systemic changes, the world will become a more inclusive and supportive place for James and others like him.

What is the condition known as Angelman syndrome?

Angelman syndrome

Angelman syndrome is a rare neurological disorder resulting from alterations in a gene crucial for brain development. This syndrome impacts the nervous system, leading to significant physical and learning disabilities. While there is no cure, various therapies can help manage symptoms like seizures and gastrointestinal problems.

The condition is quite rare, affecting approximately one in 15,000 births, or around 500,000 people globally, according to the Angelman Syndrome Foundation in Aurora, Illinois. Despite the challenges it presents, individuals with Angelman syndrome generally have a normal life expectancy.

The syndrome was named after Harry Angelman, a British doctor who first recognized and described the condition in 1965.

What are the signs and symptoms of Angelman syndrome?

According to the National Institute of Neurological Disorders and Stroke, Angelman syndrome presents with various symptoms, including developmental delays, intellectual disabilities, severe speech impairment, and issues with balance. Other common symptoms include seizures, and problems related to the gastrointestinal system, orthopedic health, and vision. Some individuals may also display unique behaviors, such as hand flapping or walking with their arms uplifted, as noted by the Mayo Clinic.

While lifelong care is often necessary for those with Angelman syndrome, certain symptoms like sleep disturbances and seizures may become less severe with age.

Colin Farrell reflected on his son James’s early years, recalling that he was an unusually quiet baby. “James was a very silent baby … he didn’t make any sounds at all. I just thought I’d hit the lottery, you know, I thought I have a chill child who’s not going to keep me up at night,” Farrell shared. However, as James grew, it became clear that he wasn’t meeting typical developmental milestones. “He wasn’t hitting benchmarks, he couldn’t sit up … he couldn’t stay up on his legs at all, so we knew something was up,” Farrell explained.

James eventually took his first steps just two weeks before his fourth birthday, a moment Farrell described as deeply moving.

Additional signs of Angelman syndrome can include frequent, unexplained laughter, a tendency to stick the tongue out, and lighter skin, hair, and eyes compared to other family members, according to the UK’s National Health Service. While blood tests can confirm the diagnosis, most babies with Angelman syndrome do not show symptoms at birth.

What leads to Angelman syndrome?

Angelman syndrome is primarily caused by changes or mutations in a specific gene known as the UBE3A gene. Normally, a child inherits two copies of each gene, one from each parent. However, Angelman syndrome occurs when there is either a missing or damaged copy of the UBE3A gene inherited from the mother. This maternal copy is crucial because it is the only active version of the UBE3A gene in certain parts of the brain.

In rare cases, Angelman syndrome can also arise when a child inherits two copies of the UBE3A gene from the father instead of one from each parent. This situation also disrupts the normal functioning of the UBE3A gene, leading to the symptoms associated with the syndrome.

The exact reasons behind the genetic changes that cause Angelman syndrome are often unclear. Researchers have not yet identified specific triggers for these changes. However, a family history of Angelman syndrome might increase the risk of the condition being passed on, suggesting that genetic factors can play a role in its occurrence.


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